IMR Press / FBL / Volume 17 / Issue 7 / DOI: 10.2741/4065

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Mechanisms and emerging functions of DNA degradation in the epidermis
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1 Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria
2 CE.R.I.E.S., Neuilly sur Seine, France
Academic Editor:Leopold Eckhart
Front. Biosci. (Landmark Ed) 2012, 17(7), 2461–2475; https://doi.org/10.2741/4065
Published: 1 June 2012
(This article belongs to the Special Issue Skin barrier)
Abstract

Degradation of DNA is involved in key processes maintaining the integrity of the epidermis such as the cornification of keratinocytes, the removal of damaged cells and the defense against potentially harmful microorganisms. Recent studies have characterized some of the molecular mechanisms and physiological functions of DNA degradation in the epidermis. Deoxyribonuclease (DNase)1L2 and TREX2 were identified as epidermis-specific DNases and DNase 2 was shown to be the predominant DNA-degrading enzyme on the surface of the skin. Here we review the latest insights into the DNA catabolism in the skin and discuss open questions pertaining to the molecular biology of epidermal DNA breakdown.

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