IMR Press / FBL / Volume 17 / Issue 7 / DOI: 10.2741/4061

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The effects of dietary flavonoids on the regulation of redox inflammatory networks
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1 Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
2 Department of Experimental Medicine, University of Rome Sapienza, Rome, Italy
3 Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome, Italy
4 Department of Drug Science, University of Catania, Catania, Italy
Academic Editor:Fabio Galvano
Front. Biosci. (Landmark Ed) 2012, 17(7), 2396–2418;
Published: 1 June 2012
(This article belongs to the Special Issue Dietary approaches to prevent chronic-degenerative diseases)

Dietary flavonoids are a large family of polyphenols ubiquitously expressed in plants. Recent evidence show that flavonoids possess several anti-inflammatory activities due to their ability to scavenge reactive oxygen and nitrogen species (ROS and RNS), to inhibit the pro-inflammatory activity of ROS-generating enzymes including cyclooxygenase (COX), lipoxygenase (LOX) and inducible nitric oxide synthase (iNOS) and to modulate different intracellular signaling pathways from NF-kB to mitogen-activated protein kinases (MAPKs) through perturbation of redox-sensible networks in immune cells. This report will review current knowledge on the anti-inflammatory effects of flavonoids on immune cells focusing on their ability to modulate multiple redox-sensible pathways involved in inflammation.

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