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Article
Role of miR-155 in breast cancer
Jie Wang1, Jianhua Wu1,*
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1
Department of Surgery, Hushan Hospital, Fudan University, Shanghai, China
Front. Biosci. (Landmark Ed) 2012, 17(6), 2350–2355;
https://doi.org/10.2741/4056
Published: 1 June 2012
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
Abstract
Breast cancer is the second leading cause of death due to cancer in women. Accumulating evidence shows a correlation between overexpression of miR-155 and breast cancer development. The microRNA (miRNA) encoded by mir-155 is known to be oncogenic in multiple tumors. This review summarizes the signaling pathways that are regulated by miR-155 in breast cancer and discusses therapeutic possibilities related to miR-155.