IMR Press / FBL / Volume 17 / Issue 6 / DOI: 10.2741/4040

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
JAK and Src tyrosine kinase signaling in asthma
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1 Division of Allergy and Immunology, Department of Medicine, National Jewish Health, University of Colorado Denver, Denver, CO 80206, USA

Academic Editor: Hua Huang

Front. Biosci. (Landmark Ed) 2012, 17(6), 2107–2121; https://doi.org/10.2741/4040
Published: 1 June 2012
(This article belongs to the Special Issue Regulation of type-2 immune responses)
Abstract

Tyrosine kinases play a critical role in transducing intracellular signals from the receptors. Many receptors do not have intrinsic tyrosine kinase activity, so they rely on cytosolic and/or membrane-associated tyrosine kinases for initial signal generation. The Src and JAK family kinases are frequently associated with receptors and generate the initial cytosolic signals. These signals are then transduced to other compartments of the cytosol and to the nucleus to elicit a specific cellular response. In this review we focus on these two families of tyrosine kinases and review their involvement in activation of cells that are involved in the pathogenesis of asthma. A Th2-type immune response dominates the processes that lead to the phenotype of asthma. For this reason we give special attention to the tyrosine kinases that are involved in a Th2 response. Further we examine the involvement of tyrosine kinases in activation of mast cells, eosinophils and other cells.

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