IMR Press / FBL / Volume 17 / Issue 4 / DOI: 10.2741/4001

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Update on the epidermal differentiation complex
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1 UMR5165 CNRS, U1056 INSERM, Toulouse, France
2 U1056 INSERM, Toulouse, France
3 University of Toulouse, Toulouse, France
4 Department of Dermatology, University Hospital of Toulouse, Toulouse, France
5 Laboratoire Ecosystemes Lagunaires, UMR5119 CNRS, UM2, IFREMER, IRD, University of Montpellier 2, Montpellier, France
Front. Biosci. (Landmark Ed) 2012, 17(4), 1517–1532;
Published: 1 January 2012

On human chromosome 1q21, a 2-Mb region called the epidermal differentiation complex comprises many genes encoding structural and regulatory proteins that are of crucial importance for keratinocyte differentiation and stratum corneum properties. Apart from those for involucrin and loricrin, most of the genes are organized in four families: the genes encoding EF-hand calcium-binding proteins of the S100A family, the genes encoding the small proline rich proteins (SPRRs) and the late cornified envelope (LCE) proteins, two families of cornified cell envelope components, and the genes encoding the S100-fused type proteins (SFTPs). This review focuses on the SPRRs, LCE proteins and SFTPs. It describes their structures, their specific functions and, when known, the mechanisms involved in the regulation of their expression. It also highlights their possible involvement in skin diseases.

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