IMR Press / FBL / Volume 17 / Issue 3 / DOI: 10.2741/3966

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Liver transplantation in chronic cholestatic conditions
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1 Liver Unit, Pomeranian Medical University, Al. Powstancow Wlkp. 72, 70-111,Szczecin, Poland
2 Liver and Hepatobiliary Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom, B15 2TH
Academic Editor:Marcelo Gabriel Roma
Front. Biosci. (Landmark Ed) 2012, 17(3), 959–969;
Published: 1 January 2012
(This article belongs to the Special Issue Experimental and clinical cholestasis)

Primary biliary cirrhosis and primary sclerosing cholangitis are two most frequently encountered cholestatic condition in adults. Liver transplantation is an excellent option in patients who progress to end-stage liver disease. In these patients typical indications for liver transplantation are no different than in other conditions requiring transplantation. Liver transplantation however might be also suggested for specific indications even in patients with otherwise well preserved liver function. 5-year survival after liver transplantation in primary biliary cirrhosis was reported to be between 78 and 87%. Survival rates after liver transplantation in primary sclerosing cholangitis are considered favorable when compared to many other indications for this procedure. Nevertheless, in both primary biliary cirrhosis and primary sclerosing cholangitis recurrence of the disease after liver transplantation can be observed. Cystic fibrosis, biliary atresia, Alagille syndrome and progressive familiar intrahepatic cholestasis are cholestatic conditions in children. Liver transplantation represents an effective treatment in majority of cases fulfilling the criteria for this procedure.

Liver Transplantation
Primary Biliary Cirrhosis
Primary Sclerosing Cholangitis
Cystic Fibrosis
Biliary Atresia
Alagille Syndrome
Progressive Familial Intrahepatic Cholestasis
Byler Disease
Bile Salt Export Pump Disease
MDR3 disease
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