IMR Press / FBL / Volume 17 / Issue 2 / DOI: 10.2741/3935

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury
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1 Center for Host Defense, Inflammation, and Lung Disease (CHILD) Research, Department of Pediatrics, Pennsylvania State University College of Medicine, Pennsylvania
2 Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Pennsylvania
Academic Editor:Uday Kishore
Front. Biosci. (Landmark Ed) 2012, 17(2), 407–429; https://doi.org/10.2741/3935
Published: 1 January 2012
(This article belongs to the Special Issue Pulmonary surfactant in human health and disease)
Abstract

Pulmonary surfactant, a lipoprotein complex, maintains alveolar integrity and plays an important role in lung host defense, and control of inflammation. Altered inflammatory processes and surfactant dysfunction are well described events that occur in patients with acute or chronic lung disease that can develop secondary to a variety of insults. Genetic variants of surfactant proteins, including single nucleotide polymorphisms, haplotypes, and other genetic variations have been associated with acute and chronic lung disease throughout life in several populations and study groups. The hydrophilic surfactant proteins SP-A and SP-D, also known as collectins, in addition to their surfactant-related functions, are important innate immunity molecules as these, among others, exhibit the ability to bind and enhance clearance of a wide range of pathogens and allergens. This review focuses on published association studies of human surfactant proteins A and D genetic polymorphisms with respiratory, and non-respiratory diseases in adults, children, and newborns. The potential role of genetic variations in pulmonary disease or pathogenesis is discussed following an evaluation, and comparison of the available literature.

Keywords
SFTPA1
SFTPA2
SP-D
Polymorphism
Single Nucleotide
collectins
lung disease
review
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