IMR Press / FBL / Volume 17 / Issue 1 / DOI: 10.2741/3920

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
The role of tristetraprolin in cancer and inflammation
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1 Department of Biological Sciences and Cancer Research Center, University of South Carolina, Columbia, SC 29203
2 Novartis Institutes for BioMedical Research, Cambridge, MA 02139
Academic Editors:Kotb Abdelmohsen, Songbi Chen
Front. Biosci. (Landmark Ed) 2012, 17(1), 174–188; https://doi.org/10.2741/3920
Published: 1 January 2012
(This article belongs to the Special Issue RNA binding proteins in disease)
Abstract

Messenger RNA decay is a critical mechanism to control the expression of many inflammation- and cancer-associated genes. These transcripts are targeted for rapid degradation through AU-rich element (ARE) motifs present in the mRNA 3' untranslated region (3'UTR). Tristetraprolin (TTP) is an RNA-binding protein that plays a significant role in regulating the expression of ARE-containing mRNAs. Through its ability to bind AREs and target the bound mRNA for rapid degradation, TTP can limit the expression of a number of critical genes frequently overexpressed in inflammation and cancer. Regulation of TTP occurs on multiple levels through cellular signaling events to control transcription, mRNA turnover, phosphorylation status, cellular localization, association with other proteins, and proteosomal degradation, all of which impact TTP's ability to promote ARE-mediated mRNA decay along with decay-independent functions of TTP. This review summarizes the current understanding of post-transcriptional regulation of ARE-containing gene expression by TTP and discusses its role in maintaining homeostasis and the pathological consequences of losing TTP expression.

Keywords
Tristetraprolin
AU-rich element
mRNA decay
post-transcriptional regulation
Review
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