Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
, Alessandro Frigiola 2, Laura Masuelli 3, Laura Marzocchella 1, Ilaria Tresoldi 1, Andrea Modesti 1, Fabio Galvano 41 Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Rome, Italy. bei@med.uniroma2.it
2 Department of Cardiac Surgery, IRCSS Policlinico, S. Donato, S. Donato Milanese, Milan, Italy
3 Department of Experimental Medicine, University of Rome, Sapienza, Rome, Italy
4 Department of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, Catania, Italy
Abstract
Many epidemiologic, observational and randomized human clinical trials have demonstrated beyond doubt the protective cardiovascular effects of omega-3 polyunsaturated fatty acids (PUFAs). Cardiac myocytes protection by omega-3 PUFAs involves several mechanisms which might have a synergistic effect. This review provides a summary of the in vitro and in vivo effects of omega-3 PUFAs on cardiac myocytes health and reports the outcome of a number of clinical trials in patients consuming omega-3 PUFAs.