IMR Press / FBL / Volume 15 / Issue 2 / DOI: 10.2741/3632

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
WHAT do viruses BET on?
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1 Hannover Medical School, Institute of Virology, Hannover, Germany
2 Harvard Medical School, Department of Pathology, Boston, USA
Academic Editor:Abel Viejo-Borbolla
Front. Biosci. (Landmark Ed) 2010, 15(2), 537–549;
Published: 1 January 2010
(This article belongs to the Special Issue Human herpesviruses)

The bromodomain and ET domain (BET) proteins belong to a group of bromodomain proteins and bind acetylated histones. Two of the currently known members of this protein family were implicated in transcriptional regulation. The two most studied BET proteins Brd2 and Brd4 have been shown to bind to viral proteins of herpesviruses and papillomaviruses. These pathogens often take advantage of the cellular function of the BET proteins and exploit it for their own purposes. In some cases though, viral proteins were shown to adapt BET proteins to new virus specific functions. Additionally some retroviruses seem to encode proteins that mimic Brd4 functions and hijack Brd4-associated protein complexes to use them for their own transcription.

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