IMR Press / FBL / Volume 15 / Issue 1 / DOI: 10.2741/3613

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Cancer associated fibroblasts (CAFs) in tumor microenvironment
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1 Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University, School of Medicine, 751 N Rutledge St. PO Box 19626, Springfield, IL 627794-9626, USA
Academic Editor:Kounosuke Watabe
Front. Biosci. (Landmark Ed) 2010, 15(1), 166–179; https://doi.org/10.2741/3613
Published: 1 January 2010
(This article belongs to the Special Issue Pathogenesis of tumor progression in breast and prostate cancer)
Abstract

Cancer associated fibroblasts (CAFs) is one of the most crucial components of the tumor microenvironment which promotes the growth and invasion of cancer cells by various mechanisms. CAFs demonstrate a high degree of heterogeneity due to their various origins; however, many distinct morphological features and physiological functions of CAFs have been identified. It is becoming clear that the crosstalk between the cancer cells and the CAFs plays a key role in the progression of cancer, and understanding this mutual relationship would eventually enable us to treat cancer patients by targeting CAFs. In this review, we will discuss the latest findings on the role of CAFs in tumorigenesis and metastasis as well as potential therapeutic implication of CAFs.

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