IMR Press / FBL / Volume 15 / Issue 1 / DOI: 10.2741/3612

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Growth factors in tumor microenvironment
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1 SimmonCooper Cancer Institute, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
Academic Editor:Kounosuke Watabe
Front. Biosci. (Landmark Ed) 2010, 15(1), 151–165; https://doi.org/10.2741/3612
Published: 1 January 2010
(This article belongs to the Special Issue Pathogenesis of tumor progression in breast and prostate cancer)
Abstract

Tumor microenvironment plays a critical role in tumor initiation and progression. Components in the microenvironment can modulate the growth of tumor cells, their ability to progress and metastasize. A major venue of communication between tumor cells and their microenvironment is through polypeptide growth factors and receptors for these growth factors. This article discusses three major classes of growth-stimulatory polypeptide growth factors and receptors for these growth factors. It also discusses how deregulation of these growth factors or their receptors can drive malignant transformation and progression.

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