IMR Press / FBL / Volume 14 / Issue 8 / DOI: 10.2741/3417

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
TNF-alpha enhances engraftment of mesenchymal stem cells into infarcted myocardium
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1 Cardiovascular Research Institute, Chonnam National University, Gwanju, South Korea
2 The Heart Center of Chonnam National University Hospital, Gwangju, South Korea
3 Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
4 Division of Cardiovascular Medicine, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, Brighton, MA 02135, USA
5 Clinical Trial Center, Chonnam National University Hospital, Gwangju, South Korea

Academic Editor: Peter M. Kang

Front. Biosci. (Landmark Ed) 2009, 14(8), 2845–2856; https://doi.org/10.2741/3417
Published: 1 January 2009
(This article belongs to the Special Issue Genetic and cellular therapies in cardiovascular diseases)
Abstract

TNF-α released from ischemic heart after acute MI increases the production of other cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6) and adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). Activation of nuclear factor kappa B (NF-κB) by TNF-α, up-regulates the expression of molecules which are involved in inflammation and cell adhesion. For these reasons, we assessed the extent that treatment of MSC with tumor necrosis factor (TNF)-α modifies the characteristics of MSC, important to their engraftment in experimental myocardial infarct. Here, we show that pre-treatment of MSC prior to transplantation with tumor necrosis factor (TNF)-α increases adhesiveness, and migration of MSC in vitro and leads to increased expression of bone morphogenetic protein (BMP)-2 by MSC. Moreover, this treatment increases the rate of engraftment of MSC and improves recovery of cardiac function after myocardial infarction. These insights might provide better strategies for the treatment of myocardial infarction.

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