IMR Press / FBL / Volume 14 / Issue 8 / DOI: 10.2741/3417

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
TNF-alpha enhances engraftment of mesenchymal stem cells into infarcted myocardium
Show Less
1 Cardiovascular Research Institute, Chonnam National University, Gwanju, South Korea
2 The Heart Center of Chonnam National University Hospital, Gwangju, South Korea
3 Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
4 Division of Cardiovascular Medicine, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, Brighton, MA 02135, USA
5 Clinical Trial Center, Chonnam National University Hospital, Gwangju, South Korea

Academic Editor: Peter M. Kang

Front. Biosci. (Landmark Ed) 2009, 14(8), 2845–2856;
Published: 1 January 2009
(This article belongs to the Special Issue Genetic and cellular therapies in cardiovascular diseases)

TNF-α released from ischemic heart after acute MI increases the production of other cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6) and adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). Activation of nuclear factor kappa B (NF-κB) by TNF-α, up-regulates the expression of molecules which are involved in inflammation and cell adhesion. For these reasons, we assessed the extent that treatment of MSC with tumor necrosis factor (TNF)-α modifies the characteristics of MSC, important to their engraftment in experimental myocardial infarct. Here, we show that pre-treatment of MSC prior to transplantation with tumor necrosis factor (TNF)-α increases adhesiveness, and migration of MSC in vitro and leads to increased expression of bone morphogenetic protein (BMP)-2 by MSC. Moreover, this treatment increases the rate of engraftment of MSC and improves recovery of cardiac function after myocardial infarction. These insights might provide better strategies for the treatment of myocardial infarction.

Back to top