IMR Press / FBL / Volume 14 / Issue 6 / DOI: 10.2741/3359

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Differential calcium signalling in neuronal-glial networks
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1 Institute of Experimental Medicine, ASCR, Videnska 1083, 142 20 Prague 4, Czech Republic
2 Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, UK
Academic Editor:Peter Koulen
Front. Biosci. (Landmark Ed) 2009, 14(6), 2004–2016;
Published: 1 January 2009

Calcium ions are the probably the most ancient, the most universal and omnipresent intracellular signalling molecules, which are involved in regulation of a host of cellular functional reactions. In the nervous system Ca2+ signalling is intimately involved in information transfer and integration within neural circuits. Local Ca2+ signals or Ca2+ microdomains control neurotransmitter release; more global Ca2+ signals regulate synaptic strength and accomplish postsynaptic processing. In the glial syncytium Ca2+ ions provide for glial "Ca2+ excitability", convey long-range signalling by means of propagating Ca2+ waves and control the release of gliotransmitters. Differential Ca2+ signals in various elements of neural circuits represent therefore molecular mechanisms of integration in the nervous system.

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