IMR Press / FBL / Volume 14 / Issue 5 / DOI: 10.2741/3336

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Cognition in multiple sclerosis: a review of neuropsychological and fMRI research
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1 Kessler Medical Rehabilitation Research and Education Center, 300 Executive Drive, Suite 10, West Orange, NJ 07052, USA
2 University of Medicine and Dentistry of New Jersey – New Jersey Medical School, Department of Physical Medicine and Rehabilitation, 30 Bergen Street, Newark, NJ 07101, USA
Academic Editor:Stella Elkabes
Front. Biosci. (Landmark Ed) 2009, 14(5), 1730–1744;
Published: 1 January 2009
(This article belongs to the Special Issue Multiple sclerosis: from molecules to therapeutics)

Multiple Sclerosis (MS) is a disease of the central nervous system affecting millions of people worldwide. In addition to the disabling physical symptoms of MS, roughly 65% of individuals with MS also experience significant cognitive dysfunction, especially in the domains of learning/memory, processing speed (PS) and working memory (WM). The purpose of this review is to examine major topics in research on cognitive dysfunction, as well as review recent functional magnetic resonance imaging (fMRI) studies focusing on cognitive dysfunction in MS. Additionally, directions for future research are discussed.

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