Human genetics of diabetes mellitus in Taiwan

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Article

Pei-Lung Chen^1,2, Wei-Shiung Yang^1,3,4,*

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¹ Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

² Program in Human Genetics, Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA

³ Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan

⁴ Department of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan

Front. Biosci. (Landmark Ed) 2009, 14(12), 4535–4545; https://doi.org/10.2741/3546

Published: 1 January 2009

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Abstract

Diabetes mellitus (DM) is a disease defined by biochemical hyperglycemia. Currently it is classified into four major categories: type 1 DM (T1DM), type 2 DM (T2DM), gestational DM (GDM) and other DM. Within each category, the etiology is still heterogeneous. The pathogenesis of most DM is multi-factorial, including many genetic and environmental factors. T1DM, T2DM and GDM are polygenic. In the category of other DM, there are at least six maturity onset diabetes of the young (MODY) and many other genetic syndromes associated with DM, which are monogenic in origin. In this review, we briefly summarized the current status of genetics in DM, described what has been done in this specific area in Taiwan and discuss what should be done after the era of genome-wide association study.

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