IMR Press / FBL / Volume 13 / Issue 4 / DOI: 10.2741/2761

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Overview of bioluminescence tomography-a new molecular imaging modality

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1 Bioluminescence Tomography Laboratory, VT-WFU School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, 1880 Pratt Drive, Suite 2000, MC-0493, Blacksburg, VA 24061, USA
2 Department of Molecular Physiology and Biophysics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
3 Computational Bioinformatics and Bio-imaging Laboratory, Department of Electrical, Computer, and Biomedical Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, USA
Front. Biosci. (Landmark Ed) 2008, 13(4), 1281–1293;
Published: 1 January 2008

According to the NIH roadmap (1), optical molecular imaging has an instrumental role in the development of molecular medicine. Great efforts, including those with bioluminescent imaging techniques, have been made to understand the linkage between genes and phenotypic expressions in normal and disease biology. Currently, bioluminescent techniques are widely used in small animal studies. However, most of the current bioluminescent imaging techniques are done in the 2D mode. In this overview, we review bioluminescence tomography (3D mode), elaborate on its principle and multi-spectral extension, describe associated image unmixing and normalization techniques, and discuss a number of directions for technical improvements and biomedical applications.

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