IMR Press / FBL / Volume 13 / Issue 4 / DOI: 10.2741/2760

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The biological role of HGF-MET axis in tumor growth and development of metastasis
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1 Department of Transplantation, Polish-American Institute of Pediatrics, Jagiellonian University School of Medicine, Cracow, Poland
Front. Biosci. (Landmark Ed) 2008, 13(4), 1271–1280;
Published: 1 January 2008

Hepatocyte growth factor (HGF) and its receptor MET play an important role in cancer growth and metastasis. Activation of MET elicit multiple cellular responses regulating cell survival, morphogenesis, adhesion, migration, breakdown of extracellular matrix (ECM) and angiogenesis. Numerous disorders related to deregulation of HGF-MET axis have been reported. Thus, new therapeutic agents targeting HGF-MET signaling have been sought. Here, we will present data describing the role of HGF-MET axis in growth and metastasis of tumor cells together with the recent approaches to block this axis.

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