IMR Press / FBL / Volume 12 / Issue 9 / DOI: 10.2741/2309

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Inhibitory effect of nicotine on bone regeneration in mandibular distraction osteogenesis
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1 Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China
Front. Biosci. (Landmark Ed) 2007, 12(9), 3256–3262;
Published: 1 May 2007

Nicotine is the main chemical component in tobacco products and its effect on bone healing remains controversial. Distraction osteogenesis is an endogenous tissue engineering technique which provides an excellent platform to study bone healing and regeneration. This study aims to evaluate the dose dependent effect of nicotine on bone regeneration using a rabbit model of mandibular distraction osteogenesis. Twenty New Zealand white rabbits were randomly assigned to four groups: sham control, placebo control, low dose nicotine (0.75 g) and high dose nicotine (1.5 g). 60-day time release nicotine pellets or placebo pellets were implanted in the neck subcutaneous tissue of the rabbits one week before osteotomy was performed. Then after three day latency, eleven day active distraction and four week consolidation, the animals were sacrificed and subjected to examinations by radiography, micro-computed tomography and histological analysis. The significantly lower bone volume and appearance of chondrocytes in the high dose nicotine group indicated that the bone regeneration of distraction osteogenesis was compromised by high dose nicotine exposure.

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