IMR Press / FBL / Volume 12 / Issue 8 / DOI: 10.2741/2275

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
SERPINA3 (aka alpha-1-antichymotrypsin)
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1 The University of Nottingham, Division of Clinical Chemistry, Molecular Medical Sciences, Institute of Genetics, University Hospital, Queen’s Medical Centre, Nottingham, NG7 2UH, UK
Academic Editor:Philip Patston
Front. Biosci. (Landmark Ed) 2007, 12(8), 2821–2835;
Published: 1 May 2007
(This article belongs to the Special Issue Serpins in biology and medicine)

Recent advances in proteomic, transcriptomic and genomic technologies have revealed much about the ACT protein and gene. In this review, we summarize our current understanding of the structure and potential physiological roles of the ACT protein, catalogue the regulatory elements that have been implicated in expression of the ACT gene, describe its tissue-specific expression and list the single nucleotide polymorphisms (SNPs) within the gene that track ACT variability. The ACT gene has been implicated in a number of complex human disorders and its potential involvement as a risk factor for Alzheimer's disease has been the subject of intensive research. However, due to previous limitations in methodologies and inadequate sample numbers the data has been conflicting with many studies failing to be replicated. In this regard, we highlight some potential approaches, which may prove to be beneficial in future studies.

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