Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
, Michael R. Lieber 21 Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India
2 USC Norris Comprehensive Cancer Ctr., Rm. 5428, Departments of Pathology, of Biochemistry and Molecular Biology, of Biological Sciences, and of Molecular Microbiology and Immunology, 1441 Eastlake Ave., MC 9176, Los Angeles, CA 90089-9176, USA
Abstract
Recently, multiple lines of evidences have shown that non-B DNA structures within the human genes may lead to chromosomal translocations, deletions and amplifications in cancer and other human diseases. In this review, we summarize the current literature on non-B DNA structures, and discuss their role in genomic instability and diseases.