IMR Press / FBL / Volume 12 / Issue 3 / DOI: 10.2741/2119

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Mitochondrial toxins and neurodegenerative diseases
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1 Departamento de Bioquimica, Bromatologia, Toxicologia y Medicina Legal, Facultad de Farmacia University of Seville, Spain
Academic Editors:Alberto Boveris, Ana Navarro
Front. Biosci. (Landmark Ed) 2007, 12(3), 986–1007; https://doi.org/10.2741/2119
Published: 1 January 2007
(This article belongs to the Special Issue Mitochondria: physiological function, signaling and oxidative damage)
Abstract

The selective loss of a particular subset of neurons is a common feature of neurodegenerative disorders. A failure in respiratory chain complex activities in mitochondria seems to be a causative factor. The aim of this review is to describe the most important toxins affecting the mitochondrial function, which could be involved in the incidence of some of these diseases: MPTP, rotenone and 3-nitropropionic (3-NPA).

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