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Article
Mitochondrial toxins and neurodegenerative diseases
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Departamento de Bioquimica, Bromatologia, Toxicologia y Medicina Legal, Facultad de Farmacia University of Seville, Spain
Front. Biosci. (Landmark Ed) 2007, 12(3), 986–1007;
https://doi.org/10.2741/2119
Published: 1 January 2007
Abstract
The selective loss of a particular subset of neurons is a common feature of neurodegenerative disorders. A failure in respiratory chain complex activities in mitochondria seems to be a causative factor. The aim of this review is to describe the most important toxins affecting the mitochondrial function, which could be involved in the incidence of some of these diseases: MPTP, rotenone and 3-nitropropionic (3-NPA).