IMR Press / FBL / Volume 12 / Issue 3 / DOI: 10.2741/2112

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

MutS homologues hMSH4 and hMSH5: diverse functional implications in humans
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1 School of Molecular Biosciences, PO Box 644660, Washington State University, Pullman, WA 99164-4660, USA
Front. Biosci. (Landmark Ed) 2007, 12(3), 905–911;
Published: 1 January 2007

The DNA mismatch repair (MMR) pathway is one of the most critical genome surveillance systems for governing faithful transmission of genetic information during DNA replication. The functional necessity of this pathway in humans is partially reflected by the tight link between MMR gene mutations and the development of hereditary nonpolyposis colorectal cancer. Increasing evidence has suggested a broad involvement of MMR proteins in various aspects of DNA metabolism beyond the scope of DNA mismatch correction, such as in the processes of DNA damage response and homologous recombination. Though evidence is presently lacking for potential functional involvement of hMSH4 and hMSH5 in MMR, these two proteins are thought to play roles in meiotic and mitotic DNA double strand break (DSB) repair and DNA damage responses in human cells.

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