IMR Press / FBL / Volume 12 / Issue 11 / DOI: 10.2741/2377

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Potential contribution of bone marrow-derived precursors to vascular repair and lesion formation: lessons from animal models of vascular diseases
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1 Department of Cardiovascular Medicine, University of Tokyo Graduate School Medicine, Tokyo, Japan
2 Department of Advanced Clinical Science and Therapeutics, University of Tokyo Graduate School Medicine, Tokyo, Japan
Academic Editor:Vicente Andres
Front. Biosci. (Landmark Ed) 2007, 12(11), 4157–4167;
Published: 1 May 2007

Atherosclerosis is responsible for more than half of all deaths in western countries. Numerous studies have reported that exuberant accumulation of smooth muscle cells (SMCs) plays a principal role in the pathogenesis of occlusive vascular diseases. It has been assumed that SMCs derived from the adjacent medial layer migrate towards the atherosclerotic lesion, proliferate and synthesize extracellular matrix, thus contributing to atheroma growth. Although much effort has been devoted to targeting the migration and proliferation of medial SMCs, no effective therapy to prevent occlusive vascular remodeling has been established. By taking advantage of genetically-modified mice, we recently reported that bone marrow cells substantially contribute to the pathogenesis of vascular diseases. It was suggested that bone marrow cells may have the potential to give rise to vascular progenitor cells that home in the damaged vessels and differentiate into smooth muscle cells or endothelial cells, thereby contributing to vascular repair, remodeling, and lesion formation. This article summarizes what we learned from genetically-modified animals regarding the origins and the fates of vascular cells that contribute to lesion formation.

Bone marrow-derived cell
Smooth muscle cell
Neointima hyperplasia
Animal model
Graft vasculopathy
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