IMR Press / FBL / Volume 12 / Issue 11 / DOI: 10.2741/2375

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
SNPs associated with prostate cancer risk and prognosis
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1 Department of Cellular & Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA
Academic Editor:George P. Hemstreet
Front. Biosci. (Landmark Ed) 2007, 12(11), 4111–4131; https://doi.org/10.2741/2375
Published: 1 May 2007
(This article belongs to the Special Issue Genes in genitourinary neoplasia)
Abstract

Studies of the genetic influences on prostate cancer have indicated that there are familial genes that account for only a small fraction of the genetic components of prostate cancer. Many investigators have investigated the association of single nucleotide polymorphisms in candidate genes with an increased risk in prostate cancer. The types of candidates examined include genes in steroid metabolism, oxidative stress, and DNA repair as well as common variants of genes found by family studies. These analyses have identified some SNPs that are associated with prostate cancer risk. A complete genetic snapshot of prosatate cancer risk will only be obtained when all the genetic risk factors are identified and combined with other known markers of risk.

Keywords
Prostate cancer
Single Nucleotide Polymorphism
SNP
Risk
Prognosis
Genetics
Review
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