Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
1 Epidemiology Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4-B874, Seattle, WA 98109, USA
2 Department of Epidemiology, University of Washington, Box 357236, Seattle, WA 98195, USA
3 The Johns Hopkins University School of Medicine, Department of Urology, Marburg 115, 600 N. Wolfe Street, Baltimore, MD 21287, USA
Abstract
Prostate cancer (PC) is a pervasive disease both in terms of incidence and mortality, yet little is known about its etiologic factors. Twin and segregation studies provide evidence for an inherited genetic component to the etiology of PC, yet over a dozen family-based genetic linkage analyses have not been able to consistently identify susceptibility loci. This chapter will review these studies, describe the challenges of this endeavor, and describe efforts to confront these challenges, such as using larger sets of families and more homogeneous subgroups.
Keywords
- Prostate Cancer
- Susceptibility Genes
- Hereditary
- Genetic Linkage
- Review