IMR Press / FBL / Volume 12 / Issue 11 / DOI: 10.2741/2368

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Wnt pathway and breast cancer
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1 Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 751 North Rutledge PO box 19626, IL 62794-9626, USA
Academic Editor:Kounosuke Watabe
Front. Biosci. (Landmark Ed) 2007, 12(11), 4020–4033; https://doi.org/10.2741/2368
Published: 1 May 2007
(This article belongs to the Special Issue Pathogenesis of tumor progression in breast and prostate cancer)
Abstract

Breast cancer is one of the most debilitating human carcinomas with second highest mortality rate after lung cancer in women. Recent advancement in genetic and biochemical analyses has deciphered the molecular pathways involved in breast cancer development. Wnt signal has long been established to play a critical role in normal development as well as in tumorigenesis. In this review, we summarize the role of Wnt signal in the development of mammary carcinoma, the molecular mechanism via which Wnt signal exerts its malignant potential and various nodal points in the Wnt cascade that can be targeted for drug development and cancer treatment.

Keywords
Wnt
pathway
Tumor
Neoplasia
Breast cancer
Inhibitor
Review
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