IMR Press / FBL / Volume 12 / Issue 11 / DOI: 10.2741/2367

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Roles of AKT signal in breast cancer
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1 Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 751 N Rutledge St. PO box 19626 Springfield, IL 627794-9626, USA
Academic Editor:Kounosuke Watabe
Front. Biosci. (Landmark Ed) 2007, 12(11), 4011–4019;
Published: 1 May 2007
(This article belongs to the Special Issue Pathogenesis of tumor progression in breast and prostate cancer)

The PI3K/Akt pathway plays a central role in a variety of cellular processes including cell growth, proliferation, motility and survival in both normal and tumor cells. The PI3K/Akt pathway is also instrumental in epithelial mesenchymal transitions and in angiogenesis during tumorigenesis. Many of the transforming events in breast cancer are a result of enhanced signaling of the PI3K/Akt pathway. Akt therefore is considered to be a rational target for cancer therapies and inhibitors of the PI3K/Akt pathway have been identified. In this review, we discuss the recent information about the functional roles of PI3K/Akt pathway in tumorigenesis and progression of breast cancer.

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