IMR Press / FBL / Volume 12 / Issue 11 / DOI: 10.2741/2366

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The central melanocortin system and the regulation of energy balance
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1 Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA
Academic Editor:Eduardo Nillni
Front. Biosci. (Landmark Ed) 2007, 12(11), 3994–4010;
Published: 1 May 2007
(This article belongs to the Special Issue Peptides controlling energy balance regulation)

The central melanocortin system is comprised of discrete populations of neurons and circuits that play a key role in maintaining energy balance. This system can sense levels of peripheral energy stores and can integrate a variety of nutrient, neuronal and hormonal signals to regulate food intake, energy expenditure and nutrient metabolism. Disruption of this system at multiple levels causes obesity in humans and animals. This article reviews the normal physiology and regulation of the central melanocortin system, the abnormalities of this system that cause impaired energy balance in humans and in rodents and the potential to target this system for the treatment of obesity and cachexia.

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