IMR Press / FBL / Volume 12 / Issue 1 / DOI: 10.2741/2059

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Osteopontin: a novel inflammatory mediator of cardiovascular disease
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1 Department of Physiology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
2 Department ofInternal Medicine, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
3 James H Quillen Veterans Affairs Medical Center, Mountain Home, TN 37684, USA
Academic Editors:Guha Krishnaswamy, David Chi
Front. Biosci. (Landmark Ed) 2007, 12(1), 214–221; https://doi.org/10.2741/2059
Published: 1 January 2007
Abstract

Osteopontin, also called cytokine Eta-1, is a multifunctional protein containing Arg-Gly-Asp-Ser (RGDS) cell-binding sequence. . It interacts with αvβ1, αvβ3 and αvβ5 integrins and CD44 receptors. OPN is suggested to play a role during inflammation via the recruitment and retention of macrophages and T-cells to inflamed sites. OPN regulates the production of inflammatory cytokines and nitric oxide in macrophages. In this review, we will discuss diverse roles of OPN related to cardiovascular diseases, including atherosclerosis, valvular stenosis, hypertrophy, myocardial infarction and heart failure.

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