Microarray technology in the investigation of diseases of myocardium with special reference to infection

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Article

Shankar Mukherjee¹, Thomas J. Belbin¹, David C. Spray¹, Aparna Mukhopadhyay¹, Fnu Nagajyothi¹, Louis M. Weiss¹, Herbert B. Tanowitz^1,*

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¹ Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA

Academic Editor: Herbert B. Tanowitz

Front. Biosci. (Landmark Ed) 2006, 11(2), 1802–1813; https://doi.org/10.2741/1924

Published: 1 May 2006

(This article belongs to the Special Issue Infectious diseases of the myocardium)

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Abstract

Microarrays are now routinely employed to characterize gene expression of thousands of genes from a single hybridization. The genome wide gene expression profile aids in the understanding of genes that may be regulated in a particular pathological condition. This paper provides an overview of microarray technology and its recent developments followed by its usage in studies of cardiovascular disease and how it pertains to viral and parasitic infections of the heart.

Keywords

Microarray

Heart Disease

Chagas disease

Parasite

Micro-organism

Infection

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