IMR Press / FBL / Volume 11 / Issue 2 / DOI: 10.2741/1911

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium
Show Less
1 Life Sciences Division, Department of Genome Biology, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
2 Red Cell Physiology Group, New York Blood Center, New York, New York 10021
3 INSERM U665, Institut National de Transfusion Sanguine, 75015 Paris, France

Academic Editor: Philippe Gascard

Front. Biosci. (Landmark Ed) 2006, 11(2), 1646–1666; https://doi.org/10.2741/1911
Published: 1 May 2006
Abstract

Members of the protein 4.1 family of adapter proteins are expressed in a broad panel of tissues including various epithelia where they likely play an important role in maintenance of cell architecture and polarity and in control of cell proliferation. We have recently characterized the structure and distribution of three members of the protein 4.1 family, 4.1B, 4.1R and 4.1N, in mouse kidney. We describe here binding partners for renal 4.1 proteins, identified through the screening of a rat kidney yeast two-hybrid system cDNA library. The identification of putative protein 4.1-based complexes enables us to envision potential functions for 4.1 proteins in kidney: organization of signaling complexes, response to osmotic stress, protein trafficking, and control of cell proliferation. We discuss the relevance of these protein 4.1-based interactions in kidney physio-pathology in the context of their previously identified functions in other cells and tissues. Specifically, we will focus on renal 4.1 protein interactions with beta amyloid precursor protein (beta-APP), 14-3-3 proteins, and the cell swelling-activated chloride channel pICln. We also discuss the functional relevance of another member of the protein 4.1 superfamily, ezrin, in kidney physio-pathology.

Keywords
Protein 4.1
Ezrin
beta-APP
14-3-3 proteins
pICln
kidney
Epithelia
Cell
Volume
Proliferation
Review
Share
Back to top