IMR Press / FBL / Volume 11 / Issue 2 / DOI: 10.2741/1890

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Genetics of perinatal brain injury in the preterm infant
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1 Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, R3E 0L8, Canada

Academic Editor: Vineet Bhandari

Front. Biosci. (Landmark Ed) 2006, 11(2), 1371–1387;
Published: 1 May 2006
(This article belongs to the Special Issue Genetic basis for disorders affecting the premature newborn)

Due to developmental immaturity of the central nervous system, effects of an adverse intrauterine environment and need for intensive care postnatally, preterm infants are at high risk of sustaining brain injury in the perinatal period. Infants who suffer brain injury in the perinatal period are at risk for long-term neurodevelopmental sequelae. Clinical and experimental data supports a significant role for inflammatory mediators in the pathophysiology of perinatal brain injury. Abnormalities in coagulation proteins in the sick preterm newborn may accentuate the risk for intraventricular hemorrhage. Polymorphisms in TNFα, IL-1β, IL-4, IL-6 and IL-10 as well as mutations in coagulation proteins have been investigated as potential candidate genes to modify risk and or severity of perinatal brain injury. Preliminary evidence suggests a role for cytokine genes as risk modifiers for IVH and PVL.

Brain Injury
Intraventricular Hemorrhage
Periventricular Leukomalacia
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