IMR Press / FBL / Volume 11 / Issue 2 / DOI: 10.2741/1889

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article

Dendritic cells and CD4+CD25+ T regulatory cells: crosstalk between two professionals in immunity versus tolerance

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1 Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Heath, 30, Bethesda, MD 20892, USA
Front. Biosci. (Landmark Ed) 2006, 11(2), 1360–1370; https://doi.org/10.2741/1889
Published: 1 May 2006
Abstract

Dendritic cells (DCs) are professional antigen presenting cells (APCs). CD4+CD25+ T regulatory cells (T regs) are recognized as professional regulatory cells. DCs not only initiate T cell immunity by uptake, processing and presentation of specific antigens, but also induce immune tolerance by deletion of T cells and/or induction of regulatory T cells. CD4+CD25+ T regs maintain immune tolerance by suppressing the function of CD4+ and CD8+ T cells, B cells, macrophages, DCs and NK cells. It would be inconceivable that the delicate balance between immunity and tolerance could be kept impeccable without the crosstalk between DCs and CD4+CD25+ T regs. This review focuses on the recent development in our understanding of DCs and CD4+CD25+ T regs in immune tolerance, with transforming growth factor-beta (TGF-β) serving as a potential link between these two professionals.

Keywords
DCs
CD4+ CD25+ Treg
TGF-β
Foxp3
Cytokine
IL-6
IL-10
Anergy
indoleamine 2
3- dioxygenase
CTLA-4
GITR
Review
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