IMR Press / FBL / Volume 11 / Issue 2 / DOI: 10.2741/1879

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Phosphoinositides in FCgamma receptor signaling
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1 Department of Immunology, University of Toronto, Molecular and Cellular Biology Research, Sunnybrook and Women's Research Institute, Toronto, Ontario, M4N 3M5, Canada

Academic Editor: Antonio Sechi

Front. Biosci. (Landmark Ed) 2006, 11(2), 1264–1274; https://doi.org/10.2741/1879
Published: 1 May 2006
Abstract

Fcgamma receptors mediate a variety of immune responses to IgG-containing complexes. Virtually all of these responses appear to be regulated by phosphoinositides, in particular phosphatidylinositol (4,5)P2 and phosphatidylinositol (3,4,5)P3. Possible downstream effectors of phosphoinositides involved in multiple FcgammaR-mediated events are discussed, as are elements of the signaling pathways that may couple Fcgamma receptors to the enzymes of phosphoinositide metabolism.

Keywords
Phosphoinositide
Fc Receptor
Phagocytosis
ADCC
Platelets
Cytoskeleton
Inflammation
CD16
CD32
CD64
Review
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