Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
1 Department of Immunology, University of Toronto, Molecular and Cellular Biology Research, Sunnybrook and Women's Research Institute, Toronto, Ontario, M4N 3M5, Canada
Abstract
Fcgamma receptors mediate a variety of immune responses to IgG-containing complexes. Virtually all of these responses appear to be regulated by phosphoinositides, in particular phosphatidylinositol (4,5)P2 and phosphatidylinositol (3,4,5)P3. Possible downstream effectors of phosphoinositides involved in multiple FcgammaR-mediated events are discussed, as are elements of the signaling pathways that may couple Fcgamma receptors to the enzymes of phosphoinositide metabolism.
Keywords
- Phosphoinositide
- Fc Receptor
- Phagocytosis
- ADCC
- Platelets
- Cytoskeleton
- Inflammation
- CD16
- CD32
- CD64
- Review