IMR Press / FBL / Volume 11 / Issue 1 / DOI: 10.2741/1793

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Role of protein modifications mediated by transglutaminase 2 in human viral diseases
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1 Department of Biochemistry and Molecular Biology, Aging and Apoptosis Research Center (AARC), Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110-799, Korea
Front. Biosci. (Landmark Ed) 2006, 11(1), 221–231; https://doi.org/10.2741/1793
Published: 1 January 2006
Abstract

Transglutaminase 2 (TG2) belongs to a family of calcium-dependent enzymes that catalyze transamidation reaction, producing polymerized, polyaminated or deamidated proteins. Recently, a growing number of viral proteins as well as cellular proteins with which they interact have been found to be modified by TG2, suggesting a novel function for TG2 in viral pathogenesis. This review summarizes the results of relevant research, examines the mechanisms underlying TG2 function in host-virus interactions and proposes a model for viral pathogenesis involving TG2.

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