IMR Press / FBL / Volume 10 / Issue 2 / DOI: 10.2741/1624

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Mitochondrial disorders in chagasic cardiomyopathy
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1 Department of Microbiology and Immunology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA

Academic Editor: Herbert B. Tanowitz

Front. Biosci. (Landmark Ed) 2005, 10(2), 1341–1354; https://doi.org/10.2741/1624
Published: 1 May 2005
(This article belongs to the Special Issue Infectious diseases of the myocardium)
Abstract

The mitochondria play a complex multi-factorial role in the cell. Along with their primary role in energy (ATP) production, mitochondria generate reactive oxygen species (ROS) that directly or indirectly affect several cellular functions. In this article, I review the molecular, structural and functional mitochondrial abnormalities reported in chagasic cardiomyopathy. I highlight current information about the potential etiology and the pathophysiological significance of mitochondrial dysfunction in chagasic cardiomyopathy and provide a brief background of mitochondrial biogenesis and bioenergetic pathways in cardiac growth and development.

Keywords
Mitochondria
Heart
Disease
Chagas Disease
Chagasic Cardiomyopathy
Reactive Oxygen Species
Antioxidant
Respiratory Chain Complexes
Review
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