Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
1 Department of Microbiology and Immunology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
Abstract
The mitochondria play a complex multi-factorial role in the cell. Along with their primary role in energy (ATP) production, mitochondria generate reactive oxygen species (ROS) that directly or indirectly affect several cellular functions. In this article, I review the molecular, structural and functional mitochondrial abnormalities reported in chagasic cardiomyopathy. I highlight current information about the potential etiology and the pathophysiological significance of mitochondrial dysfunction in chagasic cardiomyopathy and provide a brief background of mitochondrial biogenesis and bioenergetic pathways in cardiac growth and development.
Keywords
- Mitochondria
- Heart
- Disease
- Chagas Disease
- Chagasic Cardiomyopathy
- Reactive Oxygen Species
- Antioxidant
- Respiratory Chain Complexes
- Review