IMR Press / FBL / Volume 10 / Issue 2 / DOI: 10.2741/1603

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The induction of inflammation by adenovirus vectors used for gene therapy
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1 University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1 Canada

Academic Editor: Jerome Schaack

Front. Biosci. (Landmark Ed) 2005, 10(2), 1098–1105;
Published: 1 May 2005
(This article belongs to the Special Issue Early region gene function in adenovirus vectors)

The ability to repair or enhance an individual's genetic make-up provides the sublime opportunity to ameliorate or eliminate many clinical disorders that affect mankind. Gene therapy is thus a revolutionary clinical strategy that may potentially treat an array of genetic and non-genetic diseases, as well as a novel method for drug delivery and vaccination. To these ends, adenovirus vectors are currently the most promising means to deliver specific genes of interest into target cells of the patient. A major limitation of the use of adenovirus vectors in clinical trials, however, is the rapidly induced inflammatory response against these infectious particles. This review aims to describe the cellular and molecular mechanisms involved in the adenovirus-mediated inflammatory response.

Adenovirus Vectors
Gene Therapy
Innate Immunity
Signal Transduction
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