IMR Press / FBL / Volume 10 / Issue 1 / DOI: 10.2741/1571

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Molecular aspects of vascular tissue engineering
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1 University of Pittsburgh, Department of Surgery, McGowan Institute for Regenerative Medicine, 100 Technology Drive, Pittsburgh, PA 15219, USA
2 University of Pittsburgh, Department of Bioengineering, 100 Technology Drive, Pittsburgh, PA 15219
3 University of Pittsburgh, McGowan Institute for Regenerative Medicine, 100 Technology Drive, Pittsburgh, PA 15219

Academic Editor: Shu Liu

Front. Biosci. (Landmark Ed) 2005, 10(1), 768–789; https://doi.org/10.2741/1571
Published: 1 January 2005
(This article belongs to the Special Issue Molecular and biomechanical bases of vascular tissue engineering)
Abstract

Cardiovascular disease remains the number one cause of death in the United States. Most current surgical procedures to alleviate this disease rely on the availability of suitable small diameter vascular grafts, which are constrained by several limitations. Tissue engineering brings new hope to this field, but still faces many challenges. This review focuses on the molecular aspects of the different components of vascular tissue engineering. The topics addressed include the cell type, extracellular matrix, and physical and biochemical stimulation with respect to their role in the development of a tissue engineered vascular graft.

Keywords
Vascular Tissue Engineering
Stem Cells
Molecular Biology
Integrins
Growth Factors
Extracellular Matrix
Endothelial
Smooth Muscle
Mechanobiology
Review
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