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Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

1 Jan 2016Review

Curcumin: a novel non-steroidal contraceptive with antimicrobial properties

Rajesh K. Naz 1,*, Morgan L. Lough 1, Erin K. Barthelmess 1
Affiliation
Article Info

1 Reproductive Immunology and Molecular Biology Lab, Department of Obstetrics and Gynecology, West Virginia University, School of Medicine, Health Sciences Center, Morgantown, WV 26506-9186

*Author to whom correspondence should be addressed.

Abstract

Women face unique pathologies and challenges related to the female genital tract (FGT), including vaginal infections and gynecologic cancers. Vaginal infections faced by women include bacterial vaginosis (BV), vulvovaginal candidiasis (VC), and sexually transmitted infections (STIs). Curcumin, a component of the dietary spice turmeric, has immense biological properties, including antioxidant, anti-inflammatory/immunomodulatory, and anticancer effects. It has no side effects and is well-tolerated, making it an ideal treatment modality highly desired by women. Recently, our laboratory showed, for the first time ever, that curcumin exhibits a spermicidal and broad-spectrum microbicidal activity against several species of bacteria and yeast involved in vaginal infections. Thus, it could provide a novel, non-steroidal contraceptive having both spermicidal and microbicidal properties and can be panacea in women for treatment of several FGT pathologies, including gynecologic cancers.

Keywords

  • Curcumin
  • Contraception
  • Vaginal Infection
  • Female Genital Tract
  • Review

References