Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
, Luca Scotti 2, Maria Teresa Guagnano 3, Gabriella Bosco 3, Valentina Bucciarelli 2, Emanuela Di Ilio 2, Lorenza Speranza 3, Filippo Martini 2, Tonino Bucciarelli 21 Cardiology Care Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy
2 Clinical Biochemistry, Department of Biomedical Science, G. D’Annunzio, University of Chieti, Italy
3 Department of Internal Medicine and Aging Science, University G. D’Annunzio, Chieti, Italy
*Author to whom correspondence should be addressed.
Abstract
Increased levels of asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and low plasma level of L-arginine (L-ARG) are all conditions likely to decrease nitric oxide (NO) production. Aim of this study is to evaluate ADMA, SDMA, and L-ARG plasmatic levels before and after physical exercise in patients with coronary artery disease (CAD). We studied 30 patient with mean age 52 ± 4.5 years. After inclusion in the study, before the execution of physical exercise, heparinized blood sample was drawn from an indwelling arterial line for determination of ADMA, L-ARG and SDMA (baseline values). Subsequently a blood sample was drawn after the physical exercise. The mean plasma concentrations of ADMA (0.68 ± 0.06 vs 0.48 ± 0.05 µmol/L) and SDMA (0.45 ± 0.03 vs 0.30 ± 0.03 µmol/L) were significantly lower after physical exercise in comparison to baseline value, while L-ARG mean levels were increased (44.20 ± 10.5 vs 74.13 ± 11.2 µmol/L). Physical exercise has a beneficial effect by reducing plasmatic ADMA and SDMA levels, and increasing L-ARG substrate for endothelial NO.
Keywords
- ADMA
- SDMA L-arginine
- Nitric Oxide
- Coronary Artery Disease
- Physical Exercise