IMR Press / FBE / Volume 7 / Issue 2 / DOI: 10.2741/E736

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Pathological functions of hypoxia in endometriosis
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1 Department of Physiology, College of Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan 70101, Taiwan
2 Department of Obstetrics and Gynecology, College of Medicine and Hospital, National Cheng Kung University, Tainan 70101, Taiwan

*Author to whom correspondence should be addressed.

Academic Editor: Khaleque Newaz Khan

Front. Biosci. (Elite Ed) 2015, 7(2), 352–366; https://doi.org/10.2741/E736
Published: 1 January 2015
(This article belongs to the Special Issue Frontiers in endometriosis)
Abstract

Endometriosis is one of the most common gynecological diseases that significantly reduce the life quality of affected women. Research results from the past decade clearly demonstrated that aberrant production of estrogen and cyclooxygenase-2-derived prostaglandin E2 play indispensable roles in the pathogenesis of this disease. However, the etiology of endometriosis remains obscure. Recent evidence reveals a new facet of endometriotic pathogenesis by showing that hypoxia induces the expression of many important downstream genes to regulate the implantation, survival, and maintenance of ectopic endometriotic lesions. These new findings shed lights on future investigations of delineating the etiology of endometriosis and designing new therapeutic strategy for endometriosis.

Keywords
HIF-1α
Endometriosis
Prostaglandin
Cyclooxygenase
Leptin
Angiogenesis
Review
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