IMR Press / FBE / Volume 6 / Issue 1 / DOI: 10.2741/E700

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Bio-effects of non-ionizing electromagnetic fields in context of cancer therapy
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1 Department of Regenerative Medicine and Artificial Organs, PE “Center for Life Sciences”, JSC Nazarbayev University, Unit 9, 53 Kabanbay batyr Ave., Astana 010000, Kazakhstan
2 Department of Anatomy, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Fukuoka 814-0180, Japan
3 Biomaterials and Medical Devices Research Group, School of Pharmacy and Biomedical Sciences, University of Brighton, Cockcroft Building, Lewes Road, Brighton, BN2 4GJ, United Kingdom
4 School of Engineering, JSC Nazarbayev University, Unit 6, 53 Kabanbay batyr Ave., Astana 010000, Kazakhstan
5 Nanoscience and Nanotechnology Group, Faculty of Science & Engineering, University of Brighton, Cockcroft Building, Lewes Road, Brighton, BN2 4GJ, United Kingdom

*Author to whom correspondence should be addressed.


Front. Biosci. (Elite Ed) 2014, 6(1), 175–184;
Published: 1 January 2014

Bio-effects mediated by non-ionizing electromagnetic fields (EMF) have become a hot topic of research in the last decades. This interest has been triggered by a growing public concern about the rapid expansion of telecommunication devices and possible consequences of their use on human health. Despite a feasibility study of potential negative impacts, the therapeutic advantages of EMF could be effectively harnessed for the treatment of cancer and other diseases. This review aims to examine recent findings relating to the mechanisms of action underlying the bio-effects induced by non-ionizing EMF. The potential of non-thermal and thermal effects is discussed in the context of possible applications for the induction of apoptosis, formation of reactive oxygen species, and increase of membrane permeability in malignant cells. A special emphasis has been put on the combination of EMF with magnetic nano-particles and ultrasound for cancer treatment. The review encompasses both human and animal studies.

Electromagnetic Field
Reactive Oxygen Species
Drug Delivery
Combined Therapy
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