IMR Press / FBE / Volume 5 / Issue 3 / DOI: 10.2741/E674

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Monitoring molecules in neuroscience: historical overview and current advancements

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1 Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
Academic Editor:R. N. Addy
Front. Biosci. (Elite Ed) 2013, 5(3), 947–954; https://doi.org/10.2741/E674
Published: 1 June 2013
(This article belongs to the Special Issue Subsecond dopamine signaling in the mammalian brain)
Abstract

During the last 50 years, the minimally invasive techniques for monitoring brain chemistry in vivo have significantly contributed to our current understanding of chemical neurotransmission in relation to behavior, as well as, to neuropathology and neuropharmacology of CNS disorders. This article provides a short historical overview of implantable devices including voltammetric electrodes, biosensors, microdialysis and related analytical techniques developed for monitoring and sampling brain chemistry in experimental disease models. A special emphasis is given to dopamine, which besides its important role as a neurotransmitter, could be readily detected by electrochemical techniques. Today, about 70% of all published papers applying voltammetry in the brain refer to dopamine monitoring; the corresponding percentage of brain microdialysis papers referring to dopamine is 41%.

Keywords
Neurotransmitters
Dopamine
Voltammetry
Microdialysis
Biosensors
Oxygen Electrode
Brain
Rat
Review
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