IMR Press / FBE / Volume 2 / Issue 1 / DOI: 10.2741/E64

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

S100 beta protein is increased in fetuses with neural tube defect
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1 Centre for Scientific Research, San Pietro Hospital, Fatebenefratelli, Rome
2 Department of Cardiac Surgery S. Donato Milanese University Hospital, San Donato Milanese, Italy
3 Department of Fetal Maternal and Neonatal Medicine, Cesare Arrigo Children’s Hospital, Alessandria, Italy
4 Department of Gynecology, Perinatology and Child Health, University La Sapienza, Rome

*Author to whom correspondence should be addressed.


Front. Biosci. (Elite Ed) 2010, 2(1), 47–51;
Published: 1 January 2010

We investigated the levels of S100 beta protein (S100B) in the serum of fetuses with neural tube defects (NTD), and their mother. Samples from 20 fetuses with NTD and 30 controls at the same gestational age, and their mothers, were studied. S100B protein levels were determined using Lia-mat Sangtec. kit. S100B concentrations were significantly higher in NTD fetuses (median 2.71 microg/L) than in control subjects (median 0.98 microg/L). Increased S100B levels were also found in mothers carrying fetuses with NTD compared to control and uncomplicated pregnancies. This study indicates that NTD is associated with increased serum concentration of S100B in fetuses and mothers. Moreover, it gives information on S100B levels in the fetal circulation in early-mid gestation.

brain development
neuronal tube defects
S100 protein
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