IMR Press / CEOG / Volume 50 / Issue 11 / DOI: 10.31083/j.ceog5011241
Open Access Original Research
Comparison of the Effects of Two Different Low-Doses of Isobaric Bupivacaine on Intraoperative Hemodynamics under Spinal Anaesthesia during Caesarean Section: A Randomized Controlled Trial
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1 Department of Anesthesiology and Reanimation, Ataturk University School of Medicine, 25240 Erzurum, Turkey
2 Anesthesiology Clinical Research Office, Ataturk University School of Medicine, 25240 Erzurum, Turkey
3 Department of Anesthesiology and Reanimation, Altinbas University Medicalpark Hospital, 34180 Istanbul, Turkey
4 Department of Biostatistics, Ataturk University School of Medicine, 25240 Erzurum, Turkey
5 Department of Obstetrics and Gynecology, Ataturk University School of Medicine, 25240 Erzurum, Turkey
6 Department of Obstetrics and Gynecology, Faculty of Health Sciences, Erzurum Regional Training and Research Hospital, 25240 Erzurum, Turkey
*Correspondence: adostbil@hotmail.com (Aysenur Dostbil)
Clin. Exp. Obstet. Gynecol. 2023, 50(11), 241; https://doi.org/10.31083/j.ceog5011241
Submitted: 3 July 2023 | Revised: 11 August 2023 | Accepted: 22 August 2023 | Published: 22 November 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Background: The objective of this study was to conduct a randomized controlled trial in order to examine the hemodynamic impacts of two different doses of intrathecal isobaric bupivacaine (5 mg and 7 mg) when combined with 15 µg fentanyl in the context of patients undergoing caesarean section under combined spinal epidural anesthesia. Methods: Eighty patients with American Society of Anesthesiologists physical status I and II, aged between 16–50 years, who would undergo elective caesarean section under combined spinal epidural anaesthesia were randomly allocated to Group A and Group B (n = 40, for each group). Group A patients received a solution containing 5 mg isobaric bupivacaine + 15 µg fentanyl (1.3 mL), while Group B patients received a solution containing 7 mg isobaric bupivacaine + 15 µg fentanyl (1.7 mL) intrathecally. Incidences of hypotension, intraoperative systolic blood pressure, diastolic blood pressure, heart rate, motor block resolving time, and analgesia duration were recorded. Results: Group A had a substantially lower incidence of hypotension than Group B (p = 0.022). Patients in Group B had significantly lower systolic blood pressure values at the 6th, 8th, 10th, 12th, 14th, 15th, and 30th minutes of the surgery compared to Group A (p = 0.012, p = 0.014, p = 0.005, p = 0.016, p < 0,001, p = 0.002, and p = 0.011; respectively). Both groups had similar diastolic blood pressure and heart rate values during surgery (p > 0.05). The motor block resolving time and analgesia duration were longer in Group B compared to Group A (p < 0.001 for both). Two (5%) patients in Group A and ten (25%) patients in Group B experienced postoperative itching (p = 0.012). Conclusions: We concluded that combining 5 mg isobaric bupivacaine with 15 mcg of fentanyl administered intrathecally provides adequate anaesthesia while maintaining better hemodynamic stability in patients undergoing caesarean section. Clinical Trial Registration: The study has been registered with registration number NCT05136040 on https://classic.clinicaltrials.gov/ct2/results?cond=&term=+NCT05136040&cntry=&state=&city=&dist=.

Keywords
caesarean section
hemodynamics
low dose bupivacaine
spinal anaesthesia
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