- Academic Editor
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Background: The objective of this study was to conduct a randomized
controlled trial in order to examine the hemodynamic impacts of two different
doses of intrathecal isobaric bupivacaine (5 mg and 7 mg) when combined with 15
µg fentanyl in the context of patients undergoing caesarean section
under combined spinal epidural anesthesia. Methods: Eighty patients with
American Society of Anesthesiologists physical status I and II, aged between
16–50 years, who would undergo elective caesarean section under combined spinal
epidural anaesthesia were randomly allocated to Group A and Group B (n = 40, for
each group). Group A patients received a solution containing 5 mg isobaric
bupivacaine + 15 µg fentanyl (1.3 mL), while Group B patients
received a solution containing 7 mg isobaric bupivacaine + 15 µg
fentanyl (1.7 mL) intrathecally. Incidences of hypotension, intraoperative
systolic blood pressure, diastolic blood pressure, heart rate, motor block
resolving time, and analgesia duration were recorded. Results: Group A
had a substantially lower incidence of hypotension than Group B (p =
0.022). Patients in Group B had significantly lower systolic blood pressure
values at the 6th, 8th, 10th, 12th, 14th, 15th, and 30th minutes of the surgery
compared to Group A (p = 0.012, p = 0.014, p = 0.005,
p = 0.016, p