Academic Editor: Shigeki Matsubara
Background: Maresin-1 (MaR1) plays a major role in many
inflammatory disorders. Polycystic ovary syndrome (PCOS) aside from a hormonal
disorder, an inflammation might also contribute to PCOS and its metabolic
associations. Therefore, the purpose of this prospective study first time was to
find out the blood, saliva and urine levels of MaR1 in PCOS patients and evaluate
the correlations with other metabolic and hormonal parameters.
Methods: Thirty PCOS patients and 30 matched healthy controls
were enrolled to prospective case control study. Blood, urine and saliva samples
were simultaneously collected from participants after overnight fasting. MaR1
levels in blood, urine and saliva samples were determined by enzyme-linked
immunosorbent assay. Ferriman-Gallwey score, anthropometric, hormonal and some
other metabolic parameters were also recorded. Regression analysis was preformed
to find out the relationship between MaR1, C-reactive protein (CRP) and
malondialdehyde (MDA), and hormonal and metabolic parameters.
Results: Patients with PCOS compared with control
women had higher MDA and CRP and decreased MaR1 levels. Blood, urine and saliva
MDA and MaR1 levels were similar and indicated parallel decrease or increase in
the PCOS and control groups. Furthermore, regression analysis indicated that
blood CRP and MDA was positively associated with luteinizing hormone (LH) and
fasting insulin (FI) in PCOS group (p