†These authors contributed equally.
Academic Editor: Antonio Simone Laganà
Background: To investigate whether hysteroscopic endometrial mechanical
stimulation improves pregnancy outcomes in patients undergoing in vitro
fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Methods: We
conducted a systematic search in electronic databases including PubMed, Embase,
Cochrane Library, Web of Science from their inception to Feb 20th, 2021, as well
as a manual search. All publications on the impact of hysteroscopic endometrial
mechanical stimulation on IVF/ICSI outcomes were retrieved. Two reviewers
independently screened the retrieved studies using stringent inclusion and
exclusion criteria; data were subsequently extracted, and risk of bias was
assessed. Meta-analysis of the selected studies was performed using Revman 5.3.
Results: Eight studies involving 1494 patients were eligible for
inclusion, including 5 randomized controlled trials and 3 prospective
non-randomized simultaneous controlled experimental studies. We found that
compared with the control group, hysteroscopic endometrial mechanical stimulation
effectively increased live birth rate [risk ratio (RR) = 2.15, 95% confidence
interval (CI) (1.78, 2.60), p