† These authors contributed equally.
Background: Aberrant gene expression, including protein-coding and
non-coding genes (like long non-coding RNA, lncRNA), is associated with cervical
cancer development. To reveal the possible molecular mechanisms of cervical
carcinogenesis, this study conducted high throughput sequencing along with a
bioinformatics analysis. Methods: The differentially expressed lncRNAs
and mRNAs were assessed using a microarray technique in three pairs of cervical
cancer and paracancerous tissues and analyzed using the Gene Ontology (GO) and
Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotations. Their
co-expression profiles, containing 653 nodes and 400 edges, were constructed and
analyzed using Pearson’s correlation and lncRNA-mRNA co-expression network
analyses. Results: There were 242 lncRNAs and 169 mRNAs upregulated and
1204 lncRNAs and 1131 mRNAs downregulated in cervical cancer (fold change