IMR Press / FBL / Volume 9 / Issue 2 / DOI: 10.2741/1370

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Cognitive function and its neural mechanisms in nonhuman primate models of aging, Alzheimer's disease, and menopause

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1 Department of Neurology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
2 Interdisciplinary Neuroscience Program, Wake Forest University School of Medicine, Winston-Salem, NC 27157
Academic Editor:Michael Taffe
Front. Biosci. (Landmark Ed) 2004, 9(2), 1899–1914; https://doi.org/10.2741/1370
Published: 1 May 2004
(This article belongs to the Special Issue Nonhuman primate models of neuropsychopathology)
Abstract

Nonhuman primates have been used as animal models in which to study cognitive changes associated with aging and age-related disease for decades. There are many advantages to using nonhuman primates for studies of aging including the capability to examine visual nonspatial cognitive processes and the ability to use operationally similar behavioral tasks to what is used with humans. Because some aspects of aging in humans do not develop naturally in nonhuman primates or do not follow the same course of natural development in monkeys, experimental models are necessary for some investigations. Research in our laboratory has identified similarities in the cognitive profiles of nonhuman primate models of aging, Alzheimer's Disease, and menopause with their human counterparts. In addition, through the use of a variety of different techniques we have used these nonhuman primate models to begin to determine the neural substrates of age-related cognitive dysfunction noted with advanced age and age-related disease. In this paper, we review our observations made in nonhuman primate models of aging, Alzheimer's Disease, and menopause and indicate areas for future research.

Keywords
Aging
Alzheimer’s disease
Menopause
Cholinergic system
Functional imaging
Memory
Attention
Animal models
Monkeys
Review
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